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SaaS: Science as a Service
This document discusses the evolution of next generation sequencing (NGS) technologies and how cloud computing is enabling new approaches to analyzing large genomic datasets. It notes that as NGS has advanced, the amount of data produced has grown exponentially, exceeding what individual researchers can handle alone. Cloud computing is allowing genomic data to be analyzed in novel ways through services that provide scalable infrastructure, platforms for analysis, and specialized software tools. The document outlines several startup companies that are leveraging clouds to offer genomic analysis as a service and discusses challenges and opportunities in this emerging field.
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SaaS: Science as a Service
- 1. 11 SaaS Science as aService Abner Huang <abnercyh@cs.nthu.edu.tw> CSBB Lab., NTHU Dec. 14, 2011 Figure from GEN News Highlights: Jul 2, 2010
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- 4. Science as aservice 4
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- 6. 7 Nature: Milestones inDNA 1977 DNA sequencing 1990 BLAST 2002 UCSC Genome browser 2004 Ensembl Figure from http://www.nature.com/milestones/miledna/timeline.html
- 7. 8 The Trend ofNGS BRIEFINGS IN BIOINFORMATICS. VOL 11. NO 5. 484 ^ 498
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- 9. 10 Personal Genome and ClinicalBusiness
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- 11. 12 NHGRI’s New SequencingProjects • Genome Sequencing – Near $85 million in the first year • Mendelian Disorders – $12 million per year • Clinical Exploration – $10.3 million per year • Informatics Tools – $20 million for four years 12 http://www.genome.gov/27546261
- 12. 13 The Trend ofNGS ivory.idyll.org/permanent/lstein-ngs-capacity.png
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- 14. 15 Solve It UsingCloud Computing http://genomebiology.com/2010/11/5/207
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- 16. 17 Biomedical Institutes hugcloud computing • J. Craig Venter Institute released JCVI CLOUD BIO-LINUX • IBM eX5 Improves Next Generation Sequencing for Sanger Institute • ISB made Trans-Proteomic Pipeline (TPP) on clouds.
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- 24. RNAseq Unified Mapper(RUM) 26
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- 28. What’s Next? • Alternativeexpression • Allelic expression • Structural variation • Epigenomics • Metagenomics • Biological data/text mining • Hapotype/Hapomap • K thousand genomes 30
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- 32. NGS economics onclouds Biomedical Researcher Instrument vendors Sequencing outsourcing Analysis outsourcing Fabless ODM Consultants 35 2 1 3 4
- 33. Voila! RNA-Seq DataAnalysis 36
- 34. 38 IaaS Infrastructure as aService PaaS Platform as a Service SaaS Software as a Service Cloud Service Models for Scientists www.spoutingshite.com/wp-content/uploads/2008/12/saas_and_cloud_computing.ppt
- 35. 39 Eating your owndog food
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- 38. Science as aservice Service as a science 42
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- 40. Service science andcloud computing • HPC on cloud computing of NGS • Data Transfer Bottlenecks • Streaming Computing • Cost of Cloud Storage • Community Cloud Developing • App. Exchange of bioinformatics 44
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