The paper presents a significant cross-correlation measurement between CMB lensing maps from the Atacama Cosmology Telescope (ACT) Data Release 6 and luminous red galaxies from the Dark Energy Spectroscopic Instrument (DESI) Legacy Survey, achieving a significance of 50σ. It analyzes the amplitude of matter density fluctuations through a tomographic approach and provides constraints on the parameter combination s×8, consistent with early-universe predictions. The findings prompt further investigation into the consistency of the ΛCDM model at lower redshift intervals, particularly below z < 0.6.