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Tissue Binding of Drugs..............pdf
The document discusses the binding of drugs in the body, detailing how drugs distribute and interact with various tissues such as the liver, kidneys, lungs, skin, and eyes. It highlights the importance of factors affecting drug distribution and emphasizes the consequences of drug accumulation in different body parts. The findings suggest that drug interactions and binding are crucial for understanding their pharmacokinetics and potential toxicity.
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Tissue Binding of Drugs..............pdf
- 1. Bio bhammauubts Phomocokinale Binding (Taukocalgpkon Brugs) vis upotots . Dug () inqTzast abþanant volumu x i -drug binding à imporont in distihuhion from foctors inlunung Jocabzaton drugs in Hsns in dides J Uoil distihut'on ddugs whilu plasma- þrokin binding duraas1 it. () Tau-drug binding susulbs in Jocaliyaton adug sita in the body. Livar > kidnay > Lung By-Dr. Mokundra Pratap Singk Dr. Parjanya Shukla Dr. M. P. Singh Claases *The ordeY binding to exhovasculor tsuus is Mucls. shophiliuhy, þerusion Hata, strwcural eaturus o drug pH dfuunu eh. ) Liver ehoxidus onumbry haloganaht dhydrocovbons, o þorocatamo! bind iAveisibly to liier tsuws Msuling in Repao oxieiky. 9 Lungo t banic drugs ibe imipramin,chlorhromazine and ont: histåmines ’ accomWat in unqs. 3) Kideny» MaBallotkionin (Aidnzy þrotern) bind to kuavy Jad, mATCUNy , and cadmium HUsult in Mnd ocu muah'on and (3) and brivty.
- 2. (4) Skin Chloroguinand þheno thiogines oceumulatz in skinby ntevocing wik malonin." (5) Eyes Rhnal pigmants centa'n malonin bind to chloroquin and þhenothiagina Husfonibl or sahnahahy (6) Haits Aaanicals, chloroquin and subortsd to dsposit in ha shalt. C) Bonus' Titacycb'n binds to bones and tath. 8) fah - Lihophibie dugs (9) Nuclic Auds - Jablau ealium from bones -’ caus hir britlns. iohantal Combonunts d ells sku DNA Dr. Parjanya Shukla þhenohiogines Dr. M. P. Singh Claases by- Dr.Makundra PraBa Singk| arcumulah in adipose Huus. intaract strmghy oih duugs Sike chloroguint and quinocvinu sUsula in du'storton d th doubl hebieal stzuchure.
- 3. Com7orision blw Plasmo-frolain-drug brnding and Ts dug bsinding Plasmoþrotain -drug binding Rovesibl ’ bindi'ng wrak bonds binding involes q. Sma! abpotnt volumu o distmbubon. 4. boes not teAultin toxicity. 5. Dialaununt is þouibl. 6. Compah hon b/w drugs Can 3. Half bfe d plasma protuin bound 3. Half dif axhovosulor Hsu drug is Jalaivzly short. baund dvugis sulaivaly Jong Ts drsq bindíng dstibuhon. Dr. Parjanya 8hukla 1.Iewibl ’ binding invalvs shong tovalent bonds. Dr. M. P. 8ingh Clases |4. 76xiuty is comm on. not oCCUY. s. Disploumunt gennally dos By-Dy. Mahendra ratap Singh 6. Tiau- drug bind'ng qannaly non-tomp~hhve.