This document discusses making scientific research and discovery more efficient through the use of machines, open data sharing, and new models of scientific collaboration. It notes that current discovery processes are still sub-optimal and lists many different names and identifiers for the same chemical compound to illustrate challenges with data disambiguation. The document advocates for streamlining search, linking to other open chemistry resources, and using data to optimize behavior, productivity and reproducibility. It presents a vision of a smarter, open alternative to the existing system and discusses rewards, incentives and changing models of authority to drive behavioral changes that can improve research.