Emulate, Inc.

We love seeing how our customers continue to push the field forward! This new study from Joram Mooiweer and colleagues at the Dept. of Genetics, University Medical Centre Groningen is a fantastic example of how culture format shapes biology—even when starting from the same iPSC-derived cells. Their head-to-head comparison shows that the Intestine-on-Chip best recapitulates key adult gut functions, including digestion, transport, and metabolism—critical features for drug absorption, DDI, and tox-focused NAMs. Huge congratulations to the team on this important and elegant work!

🎤 Great energy at the Society for Neuroscience conference yesterday! Here’s a look at Emulate's Director of Neuroscience & Discovery Biology Randy Daughters presenting the newly launched Brain-Chip R1 in the FUJIFILM Cellular Dynamics, Inc booth. Thank you to everyone who stopped by to learn about the first isogenic, five-cell Organ-Chip model of the human neurovascular unit! If you missed Randy’s talk—or want to dive deeper into the science—you’re invited to our upcoming webinar on December 9th. Randy will be joined by Emulate Senior Scientist Erin A Greguske, PhD for a more in-depth walkthrough of the Brain-Chip R1, its development, and new application data. 👉 Register here to save your spot: https://lnkd.in/eJZrywHg We hope to see you there! #BrainChip #OrganOnChip #Neuroscience #SfN2025 #BBB #NVU #CNSResearch

The newly launched Brain-Chip R1 was developed through a close partnership between Emulate and FUJIFILM Cellular Dynamics, Inc—combining FCDI’s advanced iPSC-derived cell technologies with Emulate’s next-generation Organ-on-a-Chip platform. Together, we created the first isogenic, five-cell Organ-Chip model of the human neurovascular unit designed for more predictive BBB and NVU research. 📢 If you’re attending #SfN2025, don’t miss Emulate's own Randy Daughters presenting an overview of the Brain-Chip R1 and its development in FCDI's booth! Our Director of Sales Calvin Healy is also on site to answer all your questions about getting started with Organ-on-a-Chip technology! 📍 Booth #1004 in partnership with FCDI 🕚 11:30 AM PST — Today Stop by to learn how this new model can help accelerate CNS discovery and improve translational relevance. #SfN25 #OrganChips #Neuroscience #BBB #NVU #iPSC

🧠 Introducing the Emulate Brain-Chip R1: A new benchmark for human-relevant BBB and NVU modeling! We’re excited to launch the first isogenic, five-cell Organ-Chip model of the human neurovascular unit (NVU). The Brain-Chip R1 brings together neurons, astrocytes, microglia, pericytes, and Emulate’s proprietary BMECs within a dynamic, perfused system that captures key features of the blood–brain barrier and its surrounding microenvironment. What makes Brain-Chip R1 different? ✅ Five iPSC-derived cell types, one isogenic system ✅ Resting, physiologically relevant state with the ability to mount a robust inflammatory response ✅ Streamlined, direct-to-chip workflow—no differentiation, expansion, or pre-plating ✅ Four-day experimental window for functional BBB and neuroinflammation assays ✅ Low drug absorption using the Chip-R1™ Rigid Chip for more reliable BBB transport and ADME data The Brain-Chip R1 gives researchers a comprehensive, ready-to-use platform to more accurately study BBB transport, neuroinflammation, and human-specific NVU mechanisms—bringing us one step closer to more predictive CNS drug development. 👉 Learn more about Brain-Chip R1 and how it can support your next study: https://lnkd.in/erjTjxDy #OrganChips #Neuroscience #BloodBrainBarrier #DrugDiscovery #MPS #NAMs #CNSResearch

On the latest episode of 60 Minutes, Emulate’s scientific founder, Donald Ingber, M.D., Ph.D., was featured discussing the consequences of reduced federal research funding and the threat it poses to scientific innovation in the U.S. The segment highlighted the pioneering work taking place at the Wyss Institute at Harvard University, including Organ-on-a-Chip technology—developed in Don’s lab and commercialized through Emulate—as an example of how federally funded research drives transformative breakthroughs that impact human health. We’re proud to see Dr. Ingber’s pioneering work recognized on the national stage and remain committed to advancing Organ-on-a-Chip technology to better predict human responses to drugs and diseases. Click the link below to watch the full segment (and catch Dr. Ingber around the 5:00 mark)!

Today, on behalf of the UK Government, Lord Vallance unveiled the UK Roadmap to Reduce Animal Testing in Drug Development. What’s particularly exciting is the emphasis on #OrganOnAChip, #3DBioprinting, and their integration with #AI and in silico modelling. Together, these technologies are redefining how we study human biology, offering models that are not only more humane, but also more human-relevant. However, these models need to be appropriately characterised and validated so I am also delighted to read that the UK will establish a preclinical translational models hub, the UK Centre for the Validation of Alternative Methods (UKCVAM) to accelerate the path to regulatory approval for these tools. https://lnkd.in/eExsAm9i

We’re still standing up for scientific and academic freedom, this time on 60 MINUTES.   Tune in this Sunday from 7:00PM-8:00PM to learn more about how the government’s actions are jeopardizing our research into potentially life-saving advances in medicine, like radiation countermeasures, and how these actions could dismantle America’s lead in scientific innovation. https://lnkd.in/eVN2A6-A

🚨 Last chance to register for today’s live webinar! Join us today at 11:00 AM EDT / 8:00 AM PDT / 6:00 PM CET to hear Lorenzo Ferri MD PhD (McGill University) and Donald Ingber, M.D., Ph.D. (Wyss Institute at Harvard University) discuss how patient-derived Organ-Chips are transforming personalized medicine. Discover how this breakthrough approach predicts individual patient responses to cancer therapy — outperforming organoids and marking a major advancement for precision oncology. Don’t miss this opportunity to hear directly from two leaders shaping the future of human-relevant research! 🔗 Register now: https://lnkd.in/dXrb-Aqr #OrganChips #PersonalizedMedicine #CancerResearch #PrecisionOncology #NAMs

🎃 No tricks, just treats! The Emulate October Newsletter is now live—catch up on all the action from the last month and get a sneak peak at upcoming activities!