VantAI’s Post

Introducing Neo-1: We're thrilled to announce Neo-1—the world's most advanced atomistic foundation model, unifying all-atom structure prediction and de novo generation to decode and design life's molecular structures. Neo-1 employs the latest latent diffusion techniques to reason simultaneously about molecules and their structures, replacing multiple specialist models with one versatile framework. Design: Neo-1 generates diverse, drug-like small molecules and natural proteins from sequences, properties, or partial inputs. This enables completely novel applications, such as rational molecular glue design directly from sequences. Decode: Neo-1 achieves state-of-the-art accuracy in all-atom structure prediction, excelling particularly in complex ternary systems. NeoLink: NeoLink is VantAI's experimental platform using cross-linking mass spectrometry (XLMS) to capture structural constraints across the entire proteome, which Neo-1 integrates into precise atomic models. Programmability: Highly programmable, Neo-1 supports molecular generation, protein design, structure prediction, and molecular inpainting. Neo-1 can be guided using partial structures, sequences, or desired molecular properties. Drug Discovery & Optimization: Beyond hit discovery, Neo-1 leverages experimental data, accelerating iterative optimization in drug discovery. Applications already include molecular glues, PROTACs, and antibodies, significantly streamlining the path from computational design to experimental validation. Learn more: https://www.vant.ai/neo-1 Interested in pioneering the next frontier in biology and AI research? We're hiring—contact recruiting@vant.ai. https://lnkd.in/ekF8nfPK