Developing Antibody-Oligonucleotide Conjugates: Challenges and Solutions

On this day, we honor 𝗖.𝗩. 𝗥𝗮𝗺𝗮𝗻, whose groundbreaking discovery of the Raman Effect continues to shape 𝗺𝗼𝗱𝗲𝗿𝗻 𝗮𝗻𝗮𝗹𝘆𝘁𝗶𝗰𝗮𝗹 𝘀𝗰𝗶𝗲𝗻𝗰𝗲. In today’s pharmaceutical industry, Raman spectroscopy plays a vital role — enabling fast, non-destructive analysis, supporting polymorph identification, and ensuring batch-to-batch consistency. With 𝗛𝗢𝗥𝗜𝗕𝗔’𝘀 𝗣𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗖𝗼𝗿𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝗥𝗮𝗺𝗮𝗻 𝗦𝗽𝗲𝗰𝘁𝗿𝗼𝘀𝗰𝗼𝗽𝘆 (𝗣𝗖𝗥𝗦), we’re expanding these capabilities even further — integrating particle imaging with Raman data for deeper insights into complex formulations. From discovery to drug development, Raman’s legacy drives innovation forward. #CVRaman #RamanEffect #HORIBA #ExploreTheFuture

🧬 Advancing Peptide Stability and Characterization in Biopharma   Accurate monitoring of synthetic peptide therapeutics is crucial for drug development and quality control.   Using UV-Vis second-derivative spectroscopy on the Agilent Cary 3500 Multicell UV-Vis, researchers can improve peptide characterization and stability assessment by detecting subtle spectral changes in aromatic amino acids, even when peaks overlap.   The multicell design and automated calculations brought by workstation software streamline workflows, allowing simultaneous analysis of multiple samples while preserving precious material for follow-up analysis as LC-MS.   Fast, precise, and non-destructive—ideal for biopharma labs.   📄 Read the full app note: https://lnkd.in/dA7agPpg       #AgilentEMEA #Biopharma #PeptideTherapeutics #UVVisSpectroscopy #Cary3500 

From Bottleneck to Benchmark: kbDNA’s Rituximab Biosimilar Purification Success Story Struggling with monoclonal antibody lots that just miss purity specs? We’ve been there. Our latest application note shows how kbDNA’s rapid, scalable workflow—combining targeted HIC polishing, real-time SEC overlays, and actionable SOPs—transformed a near-miss rituximab biosimilar into a QC-ready benchmark. 🔬 See the before/after SEC overlays and schematic gels ⚡️ Discover stepwise protocols for aggregate removal and endotoxin control 📈 Get practical insights for biomanufacturers, assay developers, and QC Ready to raise your biologics game? Download the full note and see how kbDNA delivers purity on demand. https://lnkd.in/ePRNxAwk #biotech #biomanufacturing #antibodypurification #rituximab #qualitycontrol #kbDNA #applicationnote

Amazing news from Brazil: Groundbreaking work of Professor Tatiana Coelho Sampaio, UFRJ, and neurosurgeon Marco Aurélio Braz de Lima joined by Laboratório Cristália, Brazilian pharmaceutical company, resulted in patients with #spinalcordinjury to walk again! This is a strong proof of resilience, it took 25 years, and great private-public partnership using a protein, polylaminin, to restore health ❣️. #biotech #greatscience #globalinnovation https://lnkd.in/eAZEZ_G6 https://lnkd.in/eJfWgCAQ https://lnkd.in/edc6XcqV

This review summarizes recent advances in the synthesis of dialkylphosphine oxides and highlights their emerging role in drug design. Since the FDA approved Brigatinib in 2017 as the first anticancer drug containing a phosphine oxide moiety, dialkylphosphine oxides have attracted increasing interest within the medicinal chemistry community. These compounds represent a promising structural motif, offering distinctive properties such as polarity, metabolic stability, and hydrogen-bonding capability. Although current synthetic methods provide useful tools, the further development of new synthetic strategies and comprehensive property profiling would provide valuable insights into their potential as versatile design elements in modern drug discovery. #dalkylphosphineoxide #brigatinib #syntheticmethods #review #drugdesign https://bit.ly/4hSv0ic

Unlock Efficient Peptide Processes from R&D to Scale-up: Your Resource Hub Is Here! Peptide therapeutics development is advancing fast, but challenges persist. Scientists face complex chemistries, tight timelines, regulatory hurdles, and sustainability demands. Early issues like poor solubility or side reactions can lead to costly bottlenecks later. We’ve curated a solution: a resource hub packed with guides, insights, and strategies. Learn how to mitigate risks during precipitation, monitor reactions in real time, and master scale-up, digitalization, and compliance. Designed for researchers and scientists, these resources will help you build robust, scalable, and sustainable processes—from first experiments to commercial production. Ready to streamline your peptide workflows? 👉 Download the resource collection today! #Peptides #Pharma #GLP-1 #PeptidesTherapeutics https://okt.to/j3zMrx

The development of targeted drug delivery research relies on Aptamer-Drug Conjugation Services because these services provide exact and dependable methods for linking drugs to aptamers. CD Bioparticles offers state-of-the-art aptamer-drug conjugation solutions that ensure high efficiency, specificity, and reproducibility.Our services enable researchers to achieve stable drug attachment through optimized conjugation methods and established protocols which preserve both drug stability and biological activity. https://lnkd.in/ghTHwv_f

🚀 Turning plans into progress at Biosimax This past quarter, we’ve made significant strides in building a robust platform for biosimilar development and market access... ✅ Cell line license and purchase agreement secured ✅ Engagement with the MHRA underway ✅ European market access arrangements in place ✅ Technical partnerships established ✅ Ongoing support from NHS collaborators Each milestone brings us closer to delivering high-quality, affordable biologics to patients across Europe and beyond 🌍. More to come soon on our partnership with Orfenix and our European strategy — watch this space. #Biosimilars #Biotech #MHRA #MarketAccess #LifeSciences #UKBiotech #HealthInnovation #Biosimax

SkinTE® is one of the few regenerative biologics pursuing BLA approval in a chronic wound indication. With no BLA-approved therapies in a chronic wound indication since 1997, the innovation and scientific rigor required to adequately impact DFUs is substantial. SkinTE is currently available for investigational use only. Learn more about our science: https://lnkd.in/gM_bec8x #Biotech #RegenerativeMedicine #Innovation

Did you know that at Coriolis Pharma we use advanced in silico modeling to accelerate drug product development? 💡 Our computational approaches help predict molecular behavior, assess stability, and reduce experimental iterations—saving time and resources while improving decision-making. From protein structure analysis to formulation risk assessment, our in silico services provide deep insights that complement laboratory data and enable smarter strategies for complex biologics. Discover how our expertise can support your development journey: 👉 Learn more about our In Silico Services: https://lnkd.in/d9Tz73yh #DrugDevelopment #InSilico #RiskMitigation #CoriolisPharma #DidYouKnow